When choosing or editing a gaming or anime PFP, focus on a strong silhouette...

https://wiki-zine.win/index.php/How_Do_I_Keep_My_Character%27s_Defining_Accessory_from_Getting_Cut_Off_in_a_Circle_Crop%3F

When choosing or editing a gaming or anime PFP, focus on a strong silhouette and high contrast to keep it clear at small sizes. Crop tightly around the face and use a simple background without text to avoid clutter